Iodine-promoted five-component reaction using fragment assembly strategy to construct dihydrooxepines
2018
Zhao, Peng | Wu, Xia | Geng, Xiao | Wang, Can | Wu, Yan-Dong | Wu, An-Xin
An iodine-promoted fragment assembly strategy for the synthesis of fused heterocycles has been established. It provides an efficient route to construct pyrazolone-oxepine-pyrazoles from phenylhydrazines, aryl methyl ketones and acetoacetate esters. Notably, acetoacetate esters play two distinct pivotal roles in the five-component reaction by realizing the unique reactivities of methyl, methylene and carbonyl groups to construct 3-methyl-5-pyrazolone skeletons and by the reaction of methyl and carbonyl groups to form a C (sp3)-O bond.
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