Asymmetric synthesis of linezolid thiazolidine-2-thione derivatives via CS2 mediated decarboxylation cyclization
2020
Cui, De-Yun | Kong, Hong-Tao | Yang, Yi | Cai, Jian-Feng | Shen, Bo-Yuan | Yan, Da-chao | Zhang, Xiu-Juan | Qu, Ying-Long | Bai, Meng-Meng | Zhang, En
A mild and cost-effective decarboxylation cyclization method was developed for the synthesis of chiral 5-substituted thiazolidine-2-thione derivatives from β-amino oxazolidinones. This reaction was mediated by CS₂ and allowed a highly stereoselective synthesis of linezolid thiazolidine-2-thione derivatives. The chirality of the linezolid base was completely retained in the final product.
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