Structural changes in the liver of mice infected with avian influenza virus subtype H5N1

Sharkova, T. V; Potapova, O. V; Shkurupiĭ, V. A; Shestopalov, A. M; Drozdov, I. G; Shestopalova, L. V

Structural changes in the liver of mice infected with avian influenza virus subtype H5N1

2008

Intranasal infection of male outbred rats with isolate of influenza A virus subtype H5N1 (A/Gs/Krasnoozerskoye/627/05) from the Novosibirsk region was followed by high mortality of experimental animals. Morphological study of liver samples revealed subtotal destructive changes in the liver parenchyma (proteinosis and centrolobular necroses), which was related to hemodynamic disorders and cytokine dysregulation. The decrease in reparative activity of hepatocytes was probably followed by hepatocellular failure and contributed to high mortality rate from this infection (up to 85%).

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Mots clés AGROVOC

animals liver liver lymphocytes mice pathology rats

Informations bibliographiques

Publié dans

Bulletin of experimental biology and medicine. Bi︠︡ulletenʹ ėksperimentalʹnoĭ biologii i medit︠︡siny

Volume 146 Numéro 2 Pagination 243 - 245 ISSN 0007-4888

Editeur

Boston : Springer US

D'autres materias

H5n1 avian influenza virus (a/gs/krasnoozerskoye/627/05); Male; Morphological study; Orthomyxoviridae infections; Hepatocytes; Influenza a virus; H5n1 subtype

Langue

anglais

Type

Text; Journal Article

Sur AGRIS depuis: 2024-02-28

Format: MODS

Fournisseur de données

Cette notice bibliographique a été fournie par National Agricultural Library

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Liens

DOI http://dx.doi.org/10.1007/s10517-008-0262-8

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