Qualea parviflora Mart.: An integrative study to validate the gastroprotective, antidiarrheal, antihemorragic and mutagenic action
2010
Mazzolin, Lucilene Patrícia | Nasser, Ana Lúcia Martiniano | Moraes, Thiago Mello | Santos, Raquel Cássia | Nishijima, Catarine Massucato | Santos, Fábio Vieira | Varanda, Eliana Aparecida | Bauab, Taís Maria | da Rocha, Lúcia Regina Machado | Di Stasi, Luis Cláudio | Vilegas, Wagner | Hiruma-Lima, Clélia Akiko
Ethnopharmacological relevance: Qualea parviflora Mart. is a medicinal species commonly found in the Brazilian Cerrado biome. Aim of the study: Based on ethnopharmacological data, methanolic extract from Qualea parviflora (QP) bark was evaluated for its antiulcer, analgesic, anti-hemorrhagic, mutagenic and anti-Helicobacter pylori activities. Material and methods: The gastroprotective action of the extract was evaluated in rodent experimental models (HCl/ethanol, ethanol or NSAID). We also evaluated mutagenic effect (Ames assay), anti-Helicobacter pylori, anti-hemorrhagic action, analgesic and inflammatory effects (hot-plate test and carrageenin-induced hind paw edema) of methanolic extract from Qualea parviflora. Results: QP (500mg/kg, p.o.) was able to protect gastric mucosa against HCl/ethanol solution (77%), absolute ethanol (97%), and also against injurious effect of NSAID (36%). When QP was challenged with sulfhydryl depletor compound, the gastroprotective action of extract was abolished. QP treatment was able to maintain the GSH level and show a concentration-dependent inhibition effect on the lipid peroxidation. QP present anti-Helicobacter pylori effect (MIC=75μg/mL), anti-hemorrhagic and antidiarrheal action but not present analgesic or anti-inflammatory effect. Conclusion: methanolic extract from Qualea parviflora had gastroprotective effect related to the increase of gastric mucosa defensive factors such PGE₂ levels and maintain the basal gastric glutathione levels. The methanolic extract also showed anti-Helicobacter pylori activity, anti-hemorrhagic effect and antioxidant action, but absence of analgesic, mutagenic and toxic effects, a profile that adds safety to its use.
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