Bio-active maneonenes and isomaneonene from the red alga Laurencia obtusa
2017
Bawakid, Nahed O. | Alarif, Walied M. | Ismail, Ali I. | El-Hefnawy, Mohamed E. | Al-Footy, Khalid O. | Al-Lihaibi, Sultan S.
Three previously undescribed compounds, maneonenes and isomaneonene derivatives; in addition to five known compounds, two cuparene, one chamigrene, and two cis-maneonenes were isolated from the Red Sea red alga Laurencia obtusa. The chemical structures of all unknown metabolites were characterized employing spectroscopic methods and then were further confirmed by single crystal X-ray analysis. Jeddahenyne A has C-5-C-12 etheric linkage and C-13-C-14 carbon-carbon double bond; Jeddahenyne B has in addition to the aforementioned etheric linkage a C-13 carbonyl function and absence of halogenation, unusual features for the maneonenes while 12-debromo-12-methoxy isomaneonene A shows unrecorded methoxylation at C-12. The apoptosis-inducing or inhibiting effect of both compounds on apoptosis of peripheral blood neutrophils was studied.
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