Risk of cancer in relation to serum concentrations of selenium and vitamins A and E: Matched case-control analysis of prospective data
1985
Salonen, Jukka T. | Salonen, Riitta | Lappetelainen, Raili | Maenpaa, Pekka H. | Alfthan, Georg | Puska, Pekka
Independent and joint associations of pre-diagnostic serum selenium (Se) and vitamin A and E levels with subsequent cancer mortality risk were assessed in a prospective study conducted in Finland, using 51 case-control pairs followed for 4 years. Patients who died of cancer had a statistically significant lower serum Se level than controls. Fatal cancer risk was almost 6 times greater among subjects in the lowest tertile of serum Se concentration relative to subjects having higher serum Se levels, while subjects having both low Se and low vitamin E serum levels had an elevated fatal cancer risk of over 11-fold. The data also indicated a higher fatal lung cancer risk among smoking men having low Se intakes. (wz)
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