The number of copies of an a-like region in the serotype-3 Marek's disease virus DNA genome is variable
1993
Reilly, J.D. | Silva, R.F.
A 1.2-kilobasepair DNA region (a-like) in the serotype-3 Marek's disease virus was directly repeated at the ends of the long (L) and short (S) components of the genome and repeated in the opposite orientation at the junction between the L and S components. Four variants from plaque-purified virus that varied in the number of copies of the a-like region were identified. The predominant variant contained one copy at both ends of the genome and at the L-S junction. Two other variants contained either one or two copies at the L end and one to three copies at the L-S junction. The fourth variant lacked the a-like region at the L end and the L-S junction. The fourth variant became the predominate species as the virus was serially passaged in cell culture.
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