Chemical constituent with cytotoxicity from Sterculia diversifolia
2021
Rabbi, Fazle | Zada, Amir | Adhikari, Achyut | Nisar, Amna | Khalil, Saifullah Khan
One new coumarin (stercularin), along with eleven known compounds, was isolated for the first time from ethyl acetate fraction of Sterculia diversifolia. The structures of isolated compounds were characterized by spectroscopic techniques such as EIMS, ¹H-NMR and ¹³C-NMR. Compound 1 showed significant cytotoxicity by brine shrimp lethality assay (LD₅₀: 8.00 μg/ml) and PC-3 cell lines protocol (IC₅₀: 3.92 ± 0.20 μg/ml), respectively.
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