Chemical constituents and aldose reductase inhibitory activities of Betula alba bark and leaves
2022
Iguchi, Tomoki | Kuroda, Minpei | Akiyama, Nanami | Hashimoto, Mariko | Mimaki, Yoshihiro
Systematic phytochemical investigation of the bark and leaves of Betula alba was independently conducted. A new cyclic diarylheptanoid glucoside (1), five diarylheptanoids (2–6), a phenylethanoid (7), a methyl salicylate glycoside (8), a dihydrobenzofuran glucoside (9), an arylbutanoid glycoside (10), two lignan glycosides (11 and 12), a flavanone glucoside (13), and a triterpene (14) were isolated from the bark of B. alba. On the other hand, two cyclic diarylheptanoids (15 and 16), five flavonoids (17–21), a phenylpropanoid (22), a phenylbutanoid glucoside (23), and a monoterpene glucoside (24) were obtained from the leaves of B. alba. The structures of the isolated compounds (1–24) were identified on the basis of one- and two-dimensional NMR spectroscopic data. Compounds 1–24 were subsequently examined for aldose reductase (AR) inhibitory activity. Compounds 14 and 17–20 moderately inhibited AR activity with IC₅₀ values ranging from 6.6 to 34 µM.
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