Copper-catalyzed chemoselective synthesis of 4-trifluoromethyl pyrazoles
2019
Lu, Jiaqing | Man, Yuning | Zhang, Yabin | Lin, Bo | Lin, Qi | Weng, Zhiqiang
A series of 4-trifluoromethyl pyrazoles have been prepared via the copper-catalyzed cycloaddition of 2-bromo-3,3,3-trifluoropropene with a variety of N-arylsydnone derivatives under mild conditions. This new protocol under optimized reaction conditions [Cu(OTf)₂/phen, DBU, CH₃CN, 35 °C] afforded 4-trifluoromethyl pyrazoles in moderate to excellent yields with excellent regioselectivity.
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