NiO-/cotton- modified nanocomposite as a medication model for bacterial-related burn infections
2017
Basiri, Azadeh | Talebian, Nasrin | Doudi, Monir
Burn injuries are one of the major global health problems. Despite aggressive local and systemic treatment to minimize infection, severe burn wounds continue to become infected with environmental and nosocomial pathogens at relatively high rates. We developed an ultrasound assisted sol–gel technique to prepare treated cotton fibers by coating fabric surface with NiO/organic polymer/enzyme matrix for in vitro evaluation of antibacterial activity. The surface modification was performed to bond more efficiently NiO nanoparticles using cellulase enzyme, to reduce initial bacterial attachment on the hydrophilic surface using poly(ethylene glycol), and to promote ultrasonic generation and to overcome agglomeration of the nanoparticles, respectively. Disk diffusion method was used to quantify the efficacy of NiO-based cottons against Pseudomonas aeruginosa and Staphylococcus aureus as two most burn wound pathogens isolated from burn wound swabs and tissue biopsies of hospitalized burn patients . Almost bacterial isolates showed high resistance to the commonly used antibiotics for burn infection treatment. In vitro antibacterial evaluation showed that the modified cottons exhibited excellent biocidal action against both high-resistant isolated Gram-positive and Gram-negative bacteria.
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