Effects of dietary myo-inositol related compounds on sucrose-mediated hepatic lipid accumulation in rats
1999
Onomi, S. | Katayama, T. | Sato, K.
We have previously shown that dietary myo-inositol and phytic acid depress elevations of hepatic lipids and of hepatic lipogenic enzymes activities in rats fed a high-sucrose diet. In the present study, we examined whether dietary phytin (Calcium magnesium phytate) normalizes the enhancements of hepatic lipid parameters caused by sucrose feeding as well as dietary myo-inositol or phytate (sodium phytate), and whether this normalizing effect of phytate is caused by a mechanism involving reduced intestinal sucrase activity. Male Wistar rats were fed a sucrose-based diet (650g/kg diet) with supplementation of myo-inositol (1g/kg diet), phytate (sodium phytate, 5.13g/kg diet) or phytin (Calcium Magnesium phytate, 4.23g/kg diet). Phytin feeding reduced liver weight, hepatic concentrations of total lipids and triglyceride, and hepatic activities of glucose-6-phosphate dehydrogenase (G6PD, EC 1.1.1.49), malic enzyme (ME, EC 1.1.1.40) and fatty acid synthetase (FAS, EC 2.3.1.85) in rats fed the sucrose-based diet as well as myo-inositol or phytate. Dietary phytate had no influence on intestinal activities of enzymes including sucrase (EC 3.2.1.48). We speculated that the ameliorative effect of dietary myo-inositol, phytate or phytin on sucrose-induced fatty liver is not mediated through altering intestinal absorption of sucrose.
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