Lack of association between polymorphism of the human cyclic GMP-dependent protein kinase gene and obesity
2005
Zakharkin, S.O. | Belay, A.T. | Fernandez, J.R. | De Luca, V. | Kennedy, J.L. | Sokolowski, M.B. | Allison, D.B.
OBJECTIVE: To investigate whether genetic variation in the cyclic GMP-dependent protein kinase gene (PRKG1) is associated with obesity. METHODS: The study included 143 individuals from New York City area, NY, USA. The subjects were sampled on the basis of body mass index (BMI): obese (BMI ranging from 33.8 to 89.5 kg/m2), and nonobese (BMI ranging from 16.0 to 29.4 kg/m2). The association between C2276T polymorphism in PRKG1 gene and obesity was tested using linear regression analysis. RESULTS: BMI levels were predicted by linear regression models adjusted for demographic factors. An analysis was performed twice: in individuals of all ethnical backgrounds and in European-Americans only. In both cases, genotype did not have a significant effect. CONCLUSION: We found no evidence that the C2276T polymorphism in the PKRG1 gene is associated with obesity.
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