Nephrotoxicity in Hybrid sparrow (Passer domesticus × Passer hispaniolensis) living near a phosphate treatment factory complex in southern Tunisia: a biochemical and histological study
2018
Amri, Nahed | Rebai, Tarek | Jardak, Neila | Badraoui, Riadh
Our study was designed to evaluate impacts of exposure to pollutants, released by the Gabès–Ghannouche factory complex of phosphate treatment, on biochemical biomarkers and histopathological indices in kidney tissues of Hybrid sparrow (Passer domesticus × Passer hispaniolensis) in Gabès city. Our results show evidence of a pronounced impairment in kidney function which is confirmed by remarkable blood chemical alterations in sparrows living in Ghannouche, the most polluted site. Moreover, superoxide dismutase and catalase activities were found to be decreased in birds sampled from the contaminated site when compared to less polluted areas. The population of sparrows feeding in Ghannouche had enhanced renal thiobarbituric acid reactive substance levels, indicating oxidative damage to membrane lipids. Some histopathological alterations were also observed including kidney interstitial dilatations. Overall, our findings demonstrated that the exposure to pollutants released by the factory complex possessed nephrotoxic by depleting renal antioxidant defense system and promoting kidney morphometric damage in sparrows. These results constitute an early warning of an ecological change in relation to human health.
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