Wax Ester Rich Oil From The Marine Crustacean, Calanus finmarchicus, is a Bioavailable Source of EPA and DHA for Human Consumption
2016
Cook, Chad M. | Larsen, Terje S. | Derrig, Linda D. | Kelly, Kathleen M. | Tande, Kurt S.
Oil from the marine copepod, Calanus finmarchicus, which contains >86 % of fatty acids present as wax esters, is a novel source of n-3 fatty acids for human consumption. In a randomized, two-period crossover study, 18 healthy adults consumed 8 capsules providing 4 g of Calanus® Oil supplying a total of 260 mg EPA and 156 mg DHA primarily as wax esters, or 1 capsule of Lovaza® providing 465 mg EPA and 375 mg DHA as ethyl esters, each with an EPA- and DHA-free breakfast. Plasma EPA and DHA were measured over a 72 h period (t = 1, 2, 4, 6, 8, 10, 12, 24, 48, and 72 h). The positive incremental area under the curve over the 72 h test period (iAUC₀₋₇₂ ₕ) for both EPA and DHA was significantly different from zero (p < 0.0001) in both test conditions, with similar findings for the iAUC₀–₂₄ ₕ and iAUC₀–₄₈ ₕ, indicating the fatty acids were absorbed. There was no difference in the plasma iAUC₀–₇₂ ₕ for EPA + DHA, or DHA individually, in response to Calanus Oil vs the ethyl ester condition; however, the iAUC₀–₄₈ ₕ and iAUC₀–₇₂ ₕ for plasma EPA in response to Calanus Oil were both significantly increased relative to the ethyl ester condition (iAUC₀–₄₈ ₕ: 381 ± 31 vs 259 ± 39 μg*h/mL, p = 0.026; iAUC₀₋₇₂ ₕ: 514 ± 47 vs 313 ± 49 μg*h/mL, p = 0.009). These data demonstrate a novel wax ester rich marine oil is a suitable alternative source of EPA and DHA for human consumption.
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