Baicalein, a natural product, selectively activating AMPKα₂ and ameliorates metabolic disorder in diet-induced mice
2012
Pu, Peng | Wang, Xin'an | Salim, Mohamed | Zhu, Li-Hua | Wang, Lang | Chen, kvo-Jv | Xiao, Jin-Feng | Deng, Wei | Shi, Hong-Wei | Jiang, Hong | Li, Hong-Liang
The aim of the present study was to determine the effect of baicalein on metabolic syndrome induced by a high-fat diet in mice. The mice developed obesity, dyslipidemia, fatty liver, diabetes and insulin resistance. These disorders were effectively normalized in baicalein-treated mice. Further investigation revealed that the inhibitory effect on inflammation and insulin resistance was mediated by inhibition of the MAPKs pathway and activation of the IRS1/PI3K/Akt pathway. The lipid-lowering effect was attributed to the blocking of synthesis way mediated by SERBP-1c, PPARγ and the increased fatty acid oxidation. All of these effects depended on AMPKα activation. These results were confirmed in the primary hepatocytes from wild type and AMPKα₂ ⁻/⁻ mice. However, the IRS-1/PI3K/AKT pathway showed no change, which may be due to the time of stimulation and concentration. Thus, these data suggested that baicalein protects mice from metabolic syndrome through an AMPKα₂-dependent mechanism involving multiple intracellular signaling pathways.
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