The effects of small intestinal colonization by fecal and colonic bacteria on intestinal function in rats
1978
Lifshitz, Fima | Wapnir, Raul A. | Wehman, Henry J. | Diaz-Bensussen, Silvia | Pergolizzi, Robert
Extract: The effects of colonic and fecal bacterial proliferation on jejunal function were studied in normal rats and in low-germ rats after intraperitoneal injections of mecamylamine HCl. Jejunal bacteriology, bile salts, ultrastructure, and transport capacity were assessed. Findings suggest that non-invasive enteric proliferation of colonic and fecal bacterial anaerobes in rats may be associated with deconjugation of bile salts, ultrastructural alterations of the intestinal epithelial cells, and a diminished jejunal transport capacity of carbohydrates and other solutes.
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