Use of a direct enzyme-linked antiglobulin test for laboratory diagnosis of immune-mediated hemolytic anemia in dogs

Jones, D.R.E.; Gruffydd-Jones, T.J.; Stokes, C.R.; Bourne, F.J.

Use of a direct enzyme-linked antiglobulin test for laboratory diagnosis of immune-mediated hemolytic anemia in dogs

1992

Jones, D.R.E. | Gruffydd-Jones, T.J. | Stokes, C.R. | Bourne, F.J.

Detection of autoantibody, complement, or both bound to RBC is an essential requirement for unequivocal diagnosis of immune-mediated hemolytic anemia in dogs. An enzyme-linked antiglobulin test was adapted for laboratory diagnosis of this disease. The refinement and routine use of this assay have allowed further observation of the pathogenesis of the disease process. In particular, degree of hemolysis can be related to the degree of RBC sensitization associated with primary immune-mediated hemolytic anemia, and this correlation is highest for IgG autoantibody. Results indicate that autoantibody isotype might have an important role in the hemolytic process.

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Mots clés AGROVOC

analysis anemia animals blood coombs test diagnosis dogs dogs hemolysis hemolytic anemia laboratory diagnosis

Informations bibliographiques

Publié dans

American journal of veterinary research

ISSN 0002-9645

Editeur

Elsevier B.V.

D'autres materias

Complement c3; Direct enzyme-linked antiglobulin test; Hemolytic; Autoimmune; Immunoglobulin g; Direct antiglobulin test; Veterinary; Dog diseases; Enzyme-linked immunosorbent assay; Reference values; Hemoglobins; Antiglobulin test; Immunoglobulin m

Langue

anglais

Type

Journal Article; Text

Sur AGRIS depuis: 2024-02-29

Format: MODS

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