Mechanism of hemolysis of canine erythrocytes induced by L-sorbose

Goto, I.; Inaba, M.; Shimizu, T.; Maede, Y.

Mechanism of hemolysis of canine erythrocytes induced by L-sorbose

1994

Goto, I. | Inaba, M. | Shimizu, T. | Maede, Y.

The cause of species difference in the susceptibility of erythrocytes to L-sorbose, and the difference in the hemolytic effect of sorbose on high potassium-containing (HK) and low potassium-containing (LK) canine erythrocytes were examined. L-sorbose was phosphorylated in canine erythrocytes, but not in human erythrocytes. Furthermore, sorbose-1-phosphate, a metabolite of L-sorbose, strongly inhibited the hexokinase of LK canine erythrocytes, but not that of HK canine erythrocytes. These results strongly indicated that inhibition of hexokinase by sorbose-1-phosphate in LK erythrocytes induced severe glycolytic limitation in these cells, resulting in hemolysis, and that HK erythrocytes are resistant to sorbose-induced hemolysis because these cells have a high hexokinase activity.

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Mots clés AGROVOC

animals blood dogs dogs enzyme activity erythrocytes erythrocytes hemolysis hemolysis hexokinase hexokinase humans inhibition kinetics metabolites pharmacology phosphorylation physiology potassium sorbose sorbose species differences

Informations bibliographiques

Publié dans

American journal of veterinary research

ISSN 0002-9645

Editeur

Multidisciplinary Digital Publishing Institute

D'autres materias

Analogs & derivatives; Erythrocyte potassium types; Biological resistance; Antagonists & inhibitors; Sorbose-1-phosphate; Interspecific variation; Hexosephosphates; In vitro techniques; Drug effects

Langue

anglais

Note

2019-12-05

Type

Text; Journal Article

Sur AGRIS depuis: 2024-02-29

Format: MODS

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