Cyclohexadepsipeptides from Acremonium sp. BCC 28424
2011
Isaka, Masahiko | Yangchum, Arunrat | Sappan, Malipan | Suvannakad, Rapheephat | Srikitikulchai, Prasert
Six new cyclohexadepsipeptides, beauvenniatins A–E (1–5), and beauvericin J (6), together with the known beauvericin (7) and enniatin B (8), were isolated from the fungus Acremonium sp. BCC 28424. The productions of minor derivatives 3–6, possessing an N-methyl-l-tyrosine, were enhanced by feeding l-tyrosine in the liquid fermentation medium. Antimalarial, antitubercular, and cytotoxic activities of these cyclodepsipeptides were evaluated.
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