Effects of dietary proteinase inhibitors from field bean (Vicia faba L.) and field-bean meal on pancreatic function in the rat
1979
Abbey, Bene W. | Norton, Geoffrey | Neale, R.J.
Male weanling rats were fed casein diets containing 1.25, 2.5, 5.0 and 10 g/kg active or autoclaved proteinase inhibitors (PI) from field bean, and raw- and autoclaved-field-bean meal (FBM) diets. After 7, 14 and 21 days on the diets, pancreas weights were measured, and pancreas and intestinal trypsin and chymotrypsin were assayed. It was concluded that the PI alone in raw-FBM diets could not entirely be responsible for the enlargement of the pancreas and the excess secretion of pancreatic enzymes. In synthetic diets PI levels of five times those in FBM were required to produce responses of similar magnitude.
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