Pathomorphological studies on battery industry effluent treated mice
2009
Rajesh, A. | Agrawal, D.K.
The present investigation was conducted to study the impact of battery industry effluent on gross and histopathological changes on various organs of mice. For the purpose of study, two weeks old 256 mice were randomly divided into four equal groups viz. control (group I), vaccinated (group II), effluent treated (group III) and vaccine+effluent treated (group IV). Groups II and IV mice were immunized with Ranikhet disease vaccine (R₂B) at every 15 day up to 120 days of experimentation. Group I was kept as control, while groups III and IV mice were given battery industry effluent daily orally ad libitum instead of drinking water. The gross and microscopic changes were primarily seen in brain, liver, kidneys and spleen of groups III and IV mice. Histopathological examination revealed mild to moderate hypermedia, degeneration of hepatocytes, more commonly the vacuolar degeneration in liver; vascular changes and degeneration of neurons in the brain; protienaceous casts, vascular changes and mononuclear infiltration in kidneys; degeneration and depletion of lymphocytes in lymphoid follicles of spleen of battery industry effluent treated mice. So, it may be concluded that heavy metals in the effluent have toxic effect on the vital organs.
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