A systematic review and meta-analysis for the primary prevention of high risk of stroke by Nao-an capsules
2022
Wang, Liuding | Fan, Xueming | Du, Wanqing | Liang, Xiao | Chen, Yifan | Shi, Jingzi | Sun, Linjuan | Shen, Wei | Zhang, Yunling
To date, Nao-an capsules are the only Chinese patent medicine primarily prescribed for the primary prevention of stroke. To evaluate the efficacy and safety of Nao-an capsules in the primary prevention of stroke in high-risk patients. A systematic review and meta-analysis of randomized controlled trials. We searched 7 electronic databases and 2 registries from inception to January 13, 2022 for relevant randomized controlled trials. Two independent investigators selected trials, collected data, and judged the risk of bias. We performed a meta-analysis using the Review Manager software. Nine randomized controlled trials involving 14 744 patients at high risk of stroke were included. Nao-an capsules reduced the risk of first stroke compared with no intervention (risk ratio [RR] = 0.49, 95 % confidence interval [CI] 0.29 to 0.82, p = 0.006) or aspirin (RR₅₀ ₘg qd = 0.47, 95 % CI 0.25 to 0.91, p = 0.03; RR₁₀₀ ₘg qd = 0.46, 95 % CI 0.22 to 0.99, p = 0.05), without increased bleeding risks. The certainty of evidence was evaluated as moderate to very low. In addition to controlling specific risk factors, Nao-an capsules might provide additional preventive effects on first stroke with an acceptable safety profile for populations at high risk of stroke. However, as current evidence is too weak, a firm recommendation depends on further confirmation from more studies with more rigorous methodology.
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