Catalytic Asymmetric Synthesis of Chiral 2-Vinylindole Scaffolds by Friedel–Crafts Reaction
2017
Arai, Takayoshi | Tsuchida, Akiko | Miyazaki, Tomoya | Awata, Atsuko
A chiral bis(imidazolidine)pyridine (PyBidine)–Ni(OTf)₂ complex smoothly catalyzed an asymmetric Friedel–Crafts reaction of 2-vinylindoles with nitroalkenes to give chiral indoles in a highly enantioselective manner while maintaining the 2-vinyl functionality. The chiral 2-vinylindoles offer unique chiral scaffolds for diverse transformations.
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