Phenazines and cancer
2012
Cimmino, A. | Evidente, A. | Mathieu, V. | Andolfi, A. | Lefranc, F. | Kornienko, A. | Kiss, R.
Covering: 2000 to 2011 Phenazines are a large group of natural and synthesised nitrogen-containing heterocycles, including more than 100 different compounds of natural origin and over 6000 synthetic compounds. Many of these compounds have been investigated as potential anti-cancer agents. Despite a large number of research publications, no recent attempt to summarise and critically evaluate the experimental findings relating to the anti-cancer activity of this class of compounds has been made. The present review fills this gap in the literature and discusses both natural and synthetic phenazines with a critical focus on in vitro, in vivo and available clinical anti-cancer activities of these compounds.
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