pH-Mediated molecular differentiation for fluorimetric quantification of chemotherapeutic drugs in human plasma
2018
Serrano, Luis A. | Yang, Ye | SalvatiCurrent address: Children's Hospital of Philadelphia, Civic Center Blvd, Philadelphia, PA 19104, USA. Elisa | Stellacci, Francesco | Krol, Silke | Guldin, Stefan
At present, drug dosage is based on standardised approaches that disregard pharmakokinetic differences between patients and lead to non-optimal efficacy and unnecessary side effects. In this work, we demonstrate the potential of pH-mediated fluorescence spectroscopy for therapeutic drug monitoring in complex media. We apply this principle to the simultaneous quantification of the chemotherapeutic prodrug Irinotecan and its active metabolite SN-38 from human plasma across the clinically relevant concentration range, i.e. from micromolar to nanomolar at molar ratios of up to 30 : 1.
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