Liver Protective Effects of Morinda citrifolia (Noni)
2008
Wang, Mian-Ying | Nowicki, Diane | Anderson, Gary | Jensen, Jarakae | West, Brett
This study evaluated the protective effects of Noni fruit juice on acute liver injury induced by carbon tetrachloride (CCl₄) in female Sprague-Dawley (SD) rats. Liver damage (micro-centrilobular necrosis) was observed in animals pretreated with 20% placebo (drinking water) + CCl₄. However, pretreatment with 20% Noni juice in drinking water + CCl₄ resulted in markedly decreased hepatotoxic lesions. Furthermore, serum alanine aminotransferase and aspartate aminotransferase levels were significantly lower in the Noni group than the placebo group. In a correlative time-dependent study, one dose of CCl₄ (0.25 mL/kg in corn oil, p.o.) in female SD rats, pretreated with 10% placebo for 12 days, caused sequential progressive hepatotoxic lesions over a 24 h period, while a protective effect from 10% Noni juice pretreatment was observed. These results suggest that Noni juice is effective in protecting the liver from extrinsic toxin exposure.
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