Renal excretion of creatinine, electrolytes, protein, and enzymes in healthy sheep

Garry, F.; Chew, D.J.; Tarr, M.J.; Hoffsis, G.F.

Renal excretion of creatinine, electrolytes, protein, and enzymes in healthy sheep

1990

Garry, F. | Chew, D.J. | Tarr, M.J. | Hoffsis, G.F.

Urinary indices of renal function and damage were measured in 6 healthy, mature ewes over a 48-hour period. Endogenous creatinine clearance, total and fractional electrolyte excretion rates, protein excretion, urine volume, and urine gamma-glutamyltransferase and beta-glucuronidase activities were measured. Significant variations in the excretion rates of creatinine, electrolytes, and protein were not found between intervals within the 48-hour urine collection period. Total urinary electrolyte excretion rates were significantly (P < 0.001) correlated with fractional electrolyte excretion rates normalized for creatinine concentration; however, coefficient of determination was low.

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