Glycogen metabolism in muscle in uremia
1980
Hörl, Walter H. | Heidland, August
Large amounts of serine fed in combination with a high calorie, mixed low-protein diet maximally stimulates glycogen synthesis in rat skeletal muscle. A protein glycogen complex was isolated from the muscle 60 hours after bilateral nephrectomy in serine-treated animals. Surgical trauma or acute uremia led to enhanced glycogenolysis with decreased glycogen content and decreased glycogen synthesis. In skeletal muscle of phosphorylase kinase-deficient (I-strain) mice, glycogen concentration was five times as high as for other test animals. There was no decrease in muscle glycogen in fasting I-strain mice after surgery. A key role for phosphorylase kinase in the pathogenesis of glycogen depletion is indicated, in acute uremia or in postoperative stress.
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