Preparation and Characterization of Microcapsules Containing Squalene
2013
Han, Lulu | Bi, Liangwu | Zhao, Zhendong | Gao, Guilin | Xing, Yali
Ethylcellulose microcapsules containing squalene were fabricated by a solvent evaporation method. The parameters of core/shell ratio, content of surfactant, encapsulation efficiency, and drug-loading rate of squalene were investigated; the Polysorbate-80 was used as surfactant in the external phase. The results showed that the optimal ethylcellulose microcapsules containing squalene were obtained with a surfactant concentration of 0.5 % and a core/shell ratio of 1:1. Under the optimal conditions, the entrapment efficiency and the drug-loading rate reached to 60.31 +/- 0.55 % and 32.76 +/- 0.30 %, respectively. The appearance and size of microcapsules were measured by scanning electron microscope and metallographic microscope. The microcapsules were spherical in shape and have a mean diameter of 103 mu m.
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