Roadmap to DILI research in Europe. A proposal from COST Action ProEuroDILINet
2024
Lucena, Mi | Villanueva-Paz, M | Alvarez-Alvarez, None | Aithal, Guruprasad Padur | Björnsson, Es | Cakan-Akdogan, G | Cubero, Fj | Esteves, Francisco | Falcon-Perez, Jm | Fromenty, Bernard | Garcia-Ruiz, C | Grove, Ji | Konu, O | Kranendonk, Michel | Kullak-Ublick, G | Miranda, Jp | Remesal-Doblado, A | Sancho-Bru, P | Nelson, L | Andrade, Rj | Daly, Ann K. | Fernandez-Checa, Jc | Universidad de Málaga [Málaga] = University of Málaga [Málaga] | Nottingham University Hospitals NHS Trust (NUH) | Landspitali National University Hospital of Iceland | Dokuz Eylül Üniversitesi = Dokuz Eylül University [Izmir] (DEÜ) | Hospital General Universitario "Gregorio Marañón" [Madrid] | Universidade Nova de Lisboa = NOVA University Lisbon (NOVA) | Ikerbasque - Basque Foundation for Science | Nutrition, Métabolismes et Cancer (NuMeCan) ; Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Universitat de Barcelona (UB) | Bilkent University [Ankara] | University hospital of Zurich [Zurich] | Universidade de Lisboa = University of Lisbon = Université de Lisbonne (ULISBOA) | The University of Edinburgh | The present study has been supported by grants from Instituto de Salud Carlos III (ISCIII) (contract numbers: PID2022–140169OB-C21; PI21/01248; PI19/00883) and from Consejería de Salud de Andalucía (contract number: PEMP-0127–2020, Spain), cofounded by the European Union. This research was funded by HORIZON-HLTH-2022-STAYHLTH-02, grant number 101095679. Funded by the European Union. Views and opinions expressed are however those of the authors only and do not necessarily reflect those of the European Union. Neither the European Union nor the granting authority can be held responsible for them. MK was partially supported by Grant UID/BIM/0009/2020 of the Portuguese Fundação para a Ciência e a Tecnologia (FCT). MVP and IAA hold Sara Borrell research contracts from ISCIII (CD21/00198 and CD20/00083, respectively). This research was supported by CIBERehd – Consorcio Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea – European Regional Development Fund. JIG and GPA are supported by NIHR Nottingham Biomedical Research Centre [NIHR203310]. The views expressed are those of the authors and not necessarily those of the National Health Service (NHS), the NIHR or the Department of Health. This publication is based upon work from COST Action “CA17112—Prospective European Drug-Induced Liver Injury Network” supported by COST (European Cooperation in Science and Technology); www.cost.eu.
International audience
Afficher plus [+] Moins [-]anglais. In the current article the aims for a constructive way forward in Drug-Induced Liver Injury (DILI) are to highlight the most important priorities in research and clinical science, therefore supporting a more informed, focused, and better funded future for European DILI research. This Roadmap aims to identify key challenges, define a shared vision across all stakeholders for the opportunities to overcome these challenges and propose a high-quality research program to achieve progress on the prediction, prevention, diagnosis and management of this condition and impact on healthcare practice in the field of DILI. This will involve 1. Creation of a database encompassing optimised case report form for prospectively identified DILI cases with well-characterised controls with competing diagnoses, biological samples, and imaging data; 2. Establishing of preclinical models to improve the assessment and prediction of hepatotoxicity in humans to guide future drug safety testing; 3. Emphasis on implementation science and 4. Enhanced collaboration between drug-developers, clinicians and regulatory scientists. This proposed operational framework will advance DILI research and may bring together basic, applied, translational and clinical research in DILI.
Afficher plus [+] Moins [-]Mots clés AGROVOC
Informations bibliographiques
Cette notice bibliographique a été fournie par Institut national de la recherche agronomique
Découvrez la collection de ce fournisseur de données dans AGRIS