Isolation, purification, and full NMR assignments of cyclopamine from Veratrum californicum
2008
Oatis Jr., John E. | Brunsfeld, Pam | Rushing, James W. | Moeller, Peter D. | Bearden, Daniel W. | Gallien, Thomas N. | Cooper IV, George
The Hedgehog signaling pathway is essential for embryogenesis and for tissue homeostasis in the adult. However, it may induce malignancies in a number of tissues when constitutively activated, and it may also have a role in other forms of normal and maladaptive growth. Cyclopamine, a naturally occurring steroidal alkaloid, specifically inhibits the Hedgehog pathway by binding directly to Smoothened, an important Hedgehog response element. To use cyclopamine as a tool to explore and/or inhibit the Hedgehog pathway in vivo, a substantial quantity is required, and as a practical matter cyclopamine has been effectively unavailable for usage in animals larger than mice.
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