DISTAG/TBCCd1 Is Required for Basal Cell Fate Determination in Ectocarpus
2018
Godfroy, Olivier | Uji, Toshiki | Nagasato, Chikako | Lipinska, Agnieszka | Scornet, Delphine | Peters, Akira, F | Avia, Komlan | Colin, Sébastien | Mignerot, Laure | Motomura, Taizo | Cock, J. Mark | Coelho, Susana | Laboratoire de Biologie Intégrative des Modèles Marins (LBI2M) ; Station biologique de Roscoff [Roscoff] (SBR) ; Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) | Institute of Algological Research [Muroran] ; Hokkaido University [Sapporo, Japan] | Bezhin Rosko | Evolutionary Biology and Ecology of Algae (EBEA) ; Station biologique de Roscoff [Roscoff] (SBR) ; Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Pontificia Universidad Católica de Chile (UC)-Universidad Austral de Chile-Centre National de la Recherche Scientifique (CNRS) | Adaptation et diversité en milieu marin (AD2M) ; Station biologique de Roscoff [Roscoff] (SBR) ; Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) | Station biologique de Roscoff [Roscoff] (SBR) ; Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS) | Uehara Memorial Foundation | UPMC | CNRS | ANR-10-BLAN-1727,Bi-cycle,Etude du cycle de vie de l'algue brune Ectocarpus siliculosus(2010) | ANR-10-BTBR-0004,IDEALG,Biotechnologies pour la valorisation des macroalgues(2010) | European Project: Interreg | European Project: 638240,H2020,ERC-2014-STG,SEXSEA(2015)
International audience
Afficher plus [+] Moins [-]anglais. Brown algae are one of the most developmentally complex groups within the eukaryotes. As in many land plants and animals, their main body axis is established early in development, when the initial cell gives rise to two daughter cells that have apical and basal identities, equivalent to shoot and root identities in land plants, respectively. We show here that mutations in the Ectocarpus DISTAG (DIS) gene lead to loss of basal structures during both the gametophyte and the sporophyte generations. Several abnormalities were observed in the germinating initial cell in dis mutants including increased cell size, disorganisation of the Golgi apparatus, disruption of the microtubule network and aberrant positioning of the nucleus. DIS encodes a TBCCd1 protein, which has a role in internal cell organization in animals, Chlamydomonas and trypanosomes.Our study highlights the key role of subcellular events within the germinating initial cell in the determination of apical/basal cell identities in a brown alga, and emphasizes the remarkable functional conservation of TBCCd1 in regulating internal cell organization across extremely distant eukaryotic groups.
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