Glutaredoxins with iron-sulphur clusters in eukaryotes - Structure, function and impact on disease
2021
Berndt, Carsten | Christ, Loïck | Rouhier, Nicolas | Mühlenhoff, Ulrich | Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf] | Interactions Arbres-Microorganismes (IAM) ; Université de Lorraine (UL)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Philipps Universität Marburg = Philipps University of Marburg | ANR-18-CE92-0016,mitoglu,Dissection des interactions moléculaires de la glutarédoxine S15 mitochondriale chez les plantes(2018)
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Afficher plus [+] Moins [-]anglais. Among the thioredoxin superfamily of proteins, the observation that numerous glutaredoxins bind iron-sulphur (Fe/S) clusters is one of the more recent and major developments concerning their functional properties. Glutaredoxins are present in most organisms. All members of the class II subfamily (including most monothiol glutaredoxins), but also some members of the class I (mostly dithiol glutaredoxins) and class III (land plant-specific monothiol or dithiol glutaredoxins) are Fe/S proteins. In glutaredoxins characterised so far, the [2Fe-2S] cluster is coordinated by two active-site cysteine residues and two molecules of non-covalently bound glutathione in homo-dimeric complexes bridged by the cluster. In contrast to dithiol glutaredoxins, monothiol glutaredoxins possess no or very little oxidoreductase activity, but have emerged as important players in cellular iron metabolism. In this review we summarise the recent developments of the most prominent Fe/S glutaredoxins in eukaryotes, the mitochondrial single domain monothiol glutaredoxin 5, the chloroplastic single domain monothiol glutar-edoxin S14 and S16, the nuclear/cytosolic multi-domain monothiol glutaredoxin 3, and the mitochondrial/cytosolic dithiol glutaredoxin 2.
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