Serological Cross-Reactivity between Merkel Cell Polyomavirus and Two Closely Related Chimpanzee Polyomaviruses
2014
Nicol, Jérôme | Liais, Etienne | Potier, Romain | Mazzoni, Elisa | Tognon, Mauro | Coursaget, Pierre | Touzé, Antoine | Infectiologie et Santé Publique (UMR ISP) ; Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT) | Association Beauval Nature pour la Conservation et la Recherche ; Partenaires INRAE | Department of Morphology, Surgery and Experimental Medicine, School of Medicine ; Università degli Studi di Ferrara = University of Ferrara (UniFE) | Antoine Touze from the "Ligue Contre le Cancer"
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Afficher plus [+] Moins [-]anglais. Phylogenetic analyses based on the major capsid protein sequence indicate that Merkel cell polyomavirus (MCPyV) and chimpanzee polyomaviruses (PtvPyV1, PtvPyV2), and similarly Trichodysplasia spinulosa-associated polyomavirus (TSPyV) and the orangutan polyomavirus (OraPyV1) are closely related. The existence of cross-reactivity between these polyomaviruses was therefore investigated. The findings indicated serological identity between the two chimpanzee polyomaviruses investigated and a high level of cross-reactivity with Merkel cell polyomavirus. In contrast, cross-reactivity was not observed between TSPyV and OraPyV1. Furthermore, specific antibodies to chimpanzee polyomaviruses were detected in chimpanzee sera by pre-incubation of sera with the different antigens, but not in human sera.
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