NMR metabolomic signatures reveal predictive plasma metabolites associated with long-termrisk of developing breast cancer
2017
Lecuyer, Lucie | Victor Bala, Agnès | Deschasaux, Mélanie | Bouchemal, Nadia | Triba, Mohamed Nawfal | Vasson, Marie-Paule | Rossary, Adrien | Demidem, Aïcha | Galan Hercberg, Pilar | Hercberg, Serge | Partula, Valentin | Le Moyec, Laurence | Srour, Bernard | Fiolet, Thibault | Latino-Martel, Paule | Kesse-Guyot, Emmanuelle | Savarin, Philippe | Touvier, Mathilde | Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)) ; Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM) | Chimie, Structures et Propriétés de Biomatériaux et d'Agents Thérapeutiques (CSPBAT) ; Université Paris 13 (UP13)-Institut Galilée-Université Sorbonne Paris Cité (USPC)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS) | Centre National de la Recherche Scientifique (CNRS) | Université Paris 13 (UP13) | Unité de Nutrition Humaine (UNH) ; Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]) | Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne) | Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP) ; UNICANCER | Hôpital Avicenne [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) | Unité de biologie intégrative des adaptations à l'exercice (UBIAE) ; Université d'Évry-Val-d'Essonne (UEVE)-Institut National de la Santé et de la Recherche Médicale (INSERM) | Institut National de la Santé et de la Recherche Médicale (INSERM) | Institut National de la Recherche Agronomique (INRA) | Conservatoire National des Arts et Métiers [Cnam] (Cnam) | Université Paris Descartes - Paris 5 (UPD5) | Université Paris Diderot - Paris 7 (UPD7) | Centre de Recherche en Nutrition Humaine (CRNH). FRA.
SESSION 4 - BREAST CANCER: FROM EXPERIMENTAL APPROACH TO CLINICAL<br/>SESSION 4 - BREAST CANCER: FROM EXPERIMENTAL APPROACH TO CLINICAL
Afficher plus [+] Moins [-]anglais. Purpose:Combination of metabolomics and epidemiological approaches opens new perspectives for groundbreaking discoveries. The aim of the present study was to investigate for the first time whether plasma non-targeted metabolomic profiles, established from a simple blood draw from healthy women, could contribute to predict the risk of developing breast cancer within the following decade and to better understand the aetiology of this complex disease.Methods:A prospective nested case-control study was set up in the SU.VI.MAX cohort, including 206 breast cancer cases diagnosed during a 13y follow-up, and 396 matched controls. Non-targeted NMR metabolomic profiles were established from baseline plasma samples. Multivariable conditional logistic regression models were computed for each individual NMR variable and for combinations of variables derived by principal component analysis.Results: Several metabolomic variables from 1D NMR spectroscopy were associated with breast cancer risk. Women characterized by higher fasting plasma levels of valine, lysine, arginine, glutamine, creatine, creatinine, and glucose and lower plasma levels of lipoproteins, lipids, glycoproteins, acetone, glycerol-derived compounds and unsaturated lipids had a higher risk of developing breast cancer. P-values ranged from 0.00007 (ORT3vsT1=0.37[0.23-0.61] for glycerol-derived compounds) to 0.04 (ORT3vsT1=1.61[1.02-2.55] for glutamine).Conclusion: This prospective study showed that baseline NMR plasma metabolomic signatures reveal predictive metabolites associated with long-term breast cancer risk. These results provide interesting insights to better understand complex mechanisms involved in breast carcinogenesis and evoke plasma metabolic disorders favourable for carcinogenesis initiation. This study may contribute to develop screening strategies for the identification of at-risk women for breast cancer well before symptoms appear
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