Pharmaceutical proteins in plants. A strategic genetic engineering approach for the production of tuberculosis antigens.
2008
Frutos, Roger | Denise, Hubert | Vivarès, Christian | Neuhaus, Jean-Marc | Vitale, Sandro | Pedrazzini, Emmanuela | Ma, Julian | Dix, Phil | Gray, John | Pezzotti, Mario | Conrad, Udo | Robinson, David | French Agricultural Research Center for International Development ; Institut National de la Recherche Agronomique (INRA) | Laboratoire Microorganismes : Génome et Environnement (LMGE) ; Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Centre National de la Recherche Scientifique (CNRS) | Laboratory of Cell and Molecular Biology ; Université de Neuchâtel = University of Neuchatel (UNINE) | Istituto di Biologia e di Biotecnologia Agraria ; Istituto di Biologia e di Biotecnologia Agraria | St. George's Hospital ; St. George's Hospital | Hamilton Institute [NUI] ; National University of Ireland [Galway] (NUI Galway) | University of Cambridge [UK] (CAM) | Università degli studi di Verona = University of Verona (UNIVR) | Universität Gatersleben ; Universität Gatersleben | Heidelberg Institut für Planzenwissenschaften ; Universität Heidelberg [Heidelberg] = Heidelberg University
International audience
Afficher plus [+] Moins [-]anglais. Tuberculosis (TB) is a re-emerging disease that is considered a major human health priority as well as an important disease of livestock. TB is also a zoonosis, and Mycobacterium tuberculosis and M. bovis, the human and bovine causative agents, respectively, are very closely related. Protection against TB is essentially achieved through vaccination with the Bacille Calmetle-Guerin (BCG) strain of M. bovis. Protection is, however, incomplete, and novel improved vaccines are currently under investigation. Production of protective antigens in transgenic plants, or "pharming," is a promising emerging approach, and a zoonosis-like TB is a good model for investigating the potential of this approach. Pharma-Planta, a European Commission-funded project and consortium, was set up to address this topic, within which a component is aimed at assessing the production efficacy and stability of the TB antigens in different compartments of the plant cell. This article is meant to introduce this promising approach for veterinary medicine by describing the ongoing project and its specific genetic engineering strategy.
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