Expression profiling of host long non-coding RNAs under ORF virus infection
2020
PANDEY, ARUNA | SAXENA, SHIKHA | KHAN, RAJA ISHAQNABI | GANDHAM, RAVI KUMAR | RAMTEKE, PRAMOD W
The present study aimed at gaining insights into the expression profile of long non-coding RNAs (lncRNAs) and coding genes of Orf virus (ORFV) infected oral mucosal tissues of sheep using RNA-Seq technology. Specifically, an expression profile and lncRNA-mRNA interaction network was inferred from a large-scale gene expression data set of sheep mucosal tissues on 0, 3, 7 and 15 days after ORFV infection. RNA-Seq profiles were obtained from the Gene Expression Omnibus (GEO) database. We found that 45, 64 and 45 lncRNAs and 1796, 2182 and 1550 coding genes were differentially expressed at early (T3), intermediate (T7) and late (T15) stages of ORFV infection in sheep mucosal tissues, respectively. Functional analysis revealed that differentially expressed long non-coding RNAs (DElncRNAs) regulate immune processes by regulating the expression level of differentially expressed coding genes (DEGs) under ORFV infection.
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