Chromosomal homology between the human and the bovine DMRT1 genes
2009
Bratus, Anna | Bugno, Monika | Klukowska-Rötzler, Jolanta | Sawinska, Malgorzata | Eggen, Andre, A. | Slota, Ewa | National Research Institute of Animal Production | Universität Bern = University of Bern = Université de Berne (UNIBE) | German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ) | Unité de recherche Génétique Biochimique et Cytogénétique (LGBC) ; Institut National de la Recherche Agronomique (INRA) | The study was financed from statutory activity, project No. N31100832/0432.
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Afficher plus [+] Moins [-]anglais. Doublesex and mab-3 related transcription factor 1 (DMRT1) is considered to be the most conserved gene among loci involved in the molecular pathways of animal sexual development. In the majority of the extensively examined vertebrates, its function is limited to the upstream or downstream testis regulators acting during embryogenesis. Our present study demonstrated the structural homology between DMRT1 orthologos in human and cattle. A BAC clone with a specific bovine sequence of the gene was used in the FISH mapping experiments. The physical localization of DMRT1 in cattle (BTA 8q17) was determined and its homology to the human locus was shown (HSA 9p24.3). Furthermore, another BAC probe, containing the sequence of the human homologue (pBACe3.6), generated hybridisation signals oil bovine metaphase chromosomes and indicated the physical location of the autosomal bovine DMRT1 locus. Further investigations of the gene in domestic animals might provide more support For its conservative status and may help in understanding the molecular mechanisms involved in the occurrence of sexual abnormalities often diagnosed in livestock.
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