Professional exposure to goats increases the risk of pneumonic-type lung adenocarcinoma: results of the IFCT-0504-Epidemio study.
2012
Lutringer-Magnin, Delphine | Girard, Nicolas | Cadranel, Jacques | Leroux, Caroline | Quoix, Elisabeth | Cottin, Vincent | del Signore, Corinne | Lebitasy, Marie-Paule | Cordier, Geneviève | Vanhems, Philippe | Mornex, Jean-François | Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE) ; Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Université de Lyon-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS) | Centre Léon Bérard [Lyon] | Interactions cellulaires tumorales et leur environnement et réponse aux agents anti-cancéreux ; Université Pierre et Marie Curie - Paris 6 (UPMC) | Rétrovirus et Pathologie Comparée (RPC) ; Institut National de la Recherche Agronomique (INRA)-École Pratique des Hautes Études (EPHE) ; Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Université de Lyon-Ecole Nationale Vétérinaire de Lyon (ENVL) | Service de pneumologie ; Centre Hospitalier Universitaire [Strasbourg] (CHU Strasbourg) ; Hôpitaux Universitaires de Strasbourg (HUS)-Hôpitaux Universitaires de Strasbourg (HUS)-Nouvel Hôpital Civil de Strasbourg ; Hôpitaux Universitaires de Strasbourg (HUS) | Department of Pneumology [Lyon] ; Hospices Civils de Lyon (HCL) | Centre de Référence des Maladies Pulmonaires Rares [Hôpital Louis Pradel - HCL] ; Hôpital Louis Pradel [CHU - HCL] ; Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL) | Service d'Hygiène, Epidémiologie et Prévention [Hôpital Edouard Herriot - HCL] ; Hôpital Edouard Herriot [CHU - HCL] ; Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL) | Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon | INRA, Universite Lyon 1, Institut National du Cancer
International audience
Afficher plus [+] Moins [-]anglais. Pneumonic-type lung adenocarcinoma (P-ADC) represents a distinct subset of lung cancer with specific clinical, radiological, and pathological features. Given the weak association with tobacco-smoking and the striking similarities with jaagsiekte sheep retrovirus (JSRV)-induced ovine pulmonary adenocarcinoma, it has been suggested that a zoonotic viral agent infecting pulmonary cells may predispose to P-ADC in humans. Our objective was to explore whether exposure to domestic small ruminants may represent a risk factor for P-ADC. We performed a multicenter case-control study recruiting patients with P-ADC as cases and patients with non-P-ADC non-small cell lung cancer as controls. A dedicated 356-item questionnaire was built to evaluate exposure to livestock. A total of 44 cases and 132 controls were included. At multivariate analysis, P-ADC was significantly more associated with female gender (Odds-ratio (OR) = 3.23, 95% confidence interval (CI): 1.32-7.87, p = 0.010), never-smoker status (OR = 3.57, 95% CI: 1.27-10.00, p = 0.015), personal history of extra-thoracic cancer before P-ADC diagnosis (OR = 3.43, 95% CI: 1.10-10.72, p = 0.034), and professional exposure to goats (OR = 5.09, 95% CI: 1.05-24.69, p = 0.043), as compared to other subtypes of lung cancer. This case-control suggests a link between professional exposure to goats and P-ADC, and prompts for further epidemiological evaluation of potential environmental risk factors for P-ADC.
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