Effect of B-vitamins and n-3 PUFA supplementation for 5 years on blood pressure in patients with CVD
2012
Szabo de Edelenyi, Fabien | Vergnaud, Anne-Claire | Ahluwalia, Namanjeet | Julia, Chantal | Hercberg, Serge | Blacher, Jacques | Galan, Pilar | Unité de Recherche en Epidémiologie Nutritionnelle (UREN) ; Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [Cnam] (Cnam)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM) | Institut National de la Recherche Agronomique (INRA) | Dept Sante Publ ; Hôpital Avicenne [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) | Université Paris Descartes - Paris 5 (UPD5) | French Ministry of Research [R02010JJ]; Ministry of Health (Direction Generale de la Sante; DGS); Sodexo; Candia; Unilever; Danone; Roche Laboratories; Merck EPROVA GS; Pierre Fabre Laboratories
International audience
Afficher plus [+] Moins [-]anglais. Certain epidemiological and experimental studies suggest that n-3 fatty acids and folate can reduce blood pressure (BP). We investigated the effect of a daily supplementation with dietary doses of B-vitamins or n-3 fatty acids for 5 years on BP in patients with a history of CVD who participated in the Supplementation en Folates et Omega-3 trial. The patients (n 2501; 1987 men and 514 women) were randomly assigned in a 2 x 2 factorial design to one of four groups: B-vitamins (5-methyl-THF (560 mu g); vitamin B-6 (3 mg) and vitamin B-12 (20 mu g)) and a placebo capsule for n-3 fatty acids; n-3 fatty acids (600mg of EPA and DHA at a ratio of 2:1) and a placebo capsule for B-vitamins; both B-vitamins and n-3 fatty acids; or placebo capsules for both treatments. The patients took two capsules daily in a double-blind manner for a median duration of 4.7 years. At baseline and annual examination for 5 years, the patients underwent a clinical examination where BP and clinical and biological parameters were assessed. No effect of supplementation with either n-3 PUFA or B-vitamins on BP was observed in crude and adjusted multivariate models. Change in BP was not associated with change in homocysteine. In conclusion, the present results do not support the routine use of dietary supplements containing B-vitamins, or of n-3 fatty acids, to reduce BP in people with prior CVD.
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