Comparison of different maximum safe levels in fortified foods and supplements using a probabilistic risk assessment approach
2010
Dufour, Ariane | Wetzler, Sandrine | Touvier, Mathilde | Lioret, Sandrine | Gioda, Jennifer | Lafay, Lionel | Dubuisson, Carine | Calamassi-Tran, Gloria | Kalonji, Esther | Margaritis, Irène | Volatier, Jean-Luc, J.L. | Direction de l'Evaluation des Risques (DER) ; Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES) | Unité d'évaluation de risques liés à la nutrition (UERN) ; Direction de l'Evaluation des Risques (DER) ; Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES) | Unité de Recherche en Epidémiologie Nutritionnelle (UREN) ; Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [Cnam] (Cnam)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM) | French Food Safety Agency (AFSSA)
International audience
Afficher plus [+] Moins [-]anglais. Different European institutions have developed mathematical models to propose maximum safe levels either for fortified foods or for dietarysupplements. The objective of the present study was to compare and check the safety of these different maximum safe levels (MSL) by usinga probabilistic risk assessment approach. The potential maximum nutritional intakes were estimated by taking into account all sources of intakes(base diet, fortified foods and dietary supplements) and compared with the tolerable upper intake levels for vitamins and minerals. This approachsimulated the consequences of both food fortification and supplementation in terms of food safety. Different scenarios were tested. They are theresult of the combination of several MSL obtained using the previous models. The study was based on the second French Individual and National Study on Food Consumption performed in 2006–7, matched with the French food nutritional composition database. The analyses were based on a sample of 1918 adults aged 18–79 years. Some MSL in fortified foods and dietary supplements obtained independently were protective enough, although some others could lead to nutritional intakes above the tolerable upper intake levels. The simulation showed that it is crucial to consider the inter-individual variability of fortified food intakes when setting MSL for foods and supplements. The risk assessment approach developed here by integrating the MSL for fortified foods and dietary supplements is useful for ensuring consumer protection. It may be subsequently used to test any other MSL for vitamins and minerals proposed in the future.
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