Assessment of In vivo antioxidant properties of Dacryodes edulis and Ficus exasperata as anti-malaria plants
2013
Omonhinmin, Conrad A. | Agbara, I. Uche
Objective: The phytochemical profile and potential anti-oxidant properties of Dacryodes edulis and Ficus exasperata were evaluated. Methods: 50mg/kg, 100mg/kg, 200mg/kg of ethanol extracts were administered to albino rats for 7days; prior to 2 days CCl4 intoxication. Control groups were; Tween 80 (placebo), CCl4 (-ve control), Vit. E (+ve control). Tissue homogenates were used for assessing the Thiobarbituric Acid Reactive Substances (TBARS) expressed as MDA (Malondialdehyde) levels, Reduced Glutathione (GSH) and Catalase (CAT) activities. Results: Phytochemical profiling of the plants showed the presence of reducing sugars, flavonoids, saponins and tannins; except alkaloids and terpenoids in F. exasperata and cardiac glycosides in D. edulis. Generally, significantly different values (P<0.05) were recorded for Blood and liver homogenates. Elevated MDA levels were observed for the CCl4 treated group (-ve control), but lower MDA levels comparable to Vit E (+ve control) were recorded for D. edulis and the 200mg/kg F. exasperata pre-treatments. CAT levels were significantly (p<0.05) raised in the 100mg/kg and 200mg/kg for blood and the 200mg/kg for liver pretreatments; than for Vit E. CCl4 reduced GSH levels were reversed significantly (P<0.05) in blood by D. edulis and by 100mg/kg and 200mg/kg F. exasperata pretreatments in blood and liver tissues. The mean dose-dependent analysis shows increasing fall in MDA levels with dosage. Conclusions: The plant extracts exhibited dose-dependent oxidative stress suppressive action. This may justify their use for the traditional preparation of the anti-malarial remedies.
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