Bacterial adhesion to animal tissues: protein determinants for recognition of extracellular matrix components
2012
Chagnot, Caroline | Listrat, Anne | Astruc, Thierry | Desvaux, Mickaël | Unité de Microbiologie (MIC) ; Institut National de la Recherche Agronomique (INRA) | Qualité des Produits Animaux (QuaPA) ; Institut National de la Recherche Agronomique (INRA) | Unité Mixte de Recherche sur les Herbivores - UMR 1213 (UMRH) ; Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS) | INRA (French National Institute for Agronomical Research); MICEL project; inter-department CEPIA/MICA (Science and Process Engineering of Agricultural Products/Microbiology and Food Chain) AIP ('Action Incitative Programmee'); 'Region Auvergne - FEDER (Fonds Europeen de Developpement Regional)'
International audience
Afficher plus [+] Moins [-]anglais. The extracellular matrix (ECM) is present within all animal tissues and organs. Actually, it surrounds the eukaryotic cells composing the four basic tissue types, i.e. epithelial, muscle, nerve and connective. ECM does not solely refer to connective tissue but composes all tissues where its composition, structure and organization vary from one tissue to another. Constituted of the four main fibrous proteins, i.e. collagen, fibronectin, laminin and elastin, ECM components form a highly structured and functional network via specific interactions. From the basement membrane to interstitial matrix, further heterogeneity exists in the organization of the ECM in various tissues and organs also depending on their physiological state. Back to a molecular level, bacterial proteins represent the most significant part of the microbial surface components recognizing adhesive matrix molecules (MSCRAMM). These cell surface proteins are secreted and localized differently in monoderm and didermLPS bacteria. While one collagen-binding domain (CBD) and different fibronectin-binding domains (FBD1 to 8) have been registered in databases, much remains to be learned on specific binding to other ECM proteins via single or supramolecular protein structures. Besides theinteraction of bacterial proteins with individual ECM components, this review aims at stressing the importance of fully considering the ECM at supramolecular, cellular, tissue and organ levels. This conceptual view should not be overlooked to rigorously comprehend the physiology of bacterial interaction from commensal to pathogenic species.
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