Antibody Responsiveness to Influenza: What Drives It?
2021
Lin, Xia | Lin, Fangmei | Liang, Tingting | Ducatez, Mariette, F. | Zanin, Mark | Wong, Sook-San | Southern Medical University [Guangzhou] | State Key Laboratory of Respiratory Diseases ; Guangzhou Institute of Respiratory Diseases-Guangzhou Medical College | Interactions hôtes-agents pathogènes [Toulouse] (IHAP) ; Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | The Chinese University of Hong Kong [Hong Kong] (CUHK) | This research was funded by Natural Science Foundation of Guangdong Province, China, (Grant number 2019A1515012070). M.Z. and S.-S.W. are supported by the High-Level University Talent Construction Program of Guangzhou Medical University (Grant numbers: 06-410-2106093, 06-410-2106092).
International audience
Afficher plus [+] Moins [-]anglais. The induction of a specific antibody response has long been accepted as a serological hallmark of recent infection or antigen exposure. Much of our understanding of the influenza antibody response has been derived from studying antibodies that target the hemagglutinin (HA) protein. However, growing evidence points to limitations associated with this approach. In this review, we aim to highlight the issue of antibody non-responsiveness after influenza virus infection and vaccination. We will then provide an overview of the major factors known to influence antibody responsiveness to influenza after infection and vaccination. We discuss the biological factors such as age, sex, influence of prior immunity, genetics, and some chronic infections that may affect the induction of influenza antibody responses. We also discuss the technical factors, such as assay choices, strain variations, and viral properties that may influence the sensitivity of the assays used to measure influenza antibodies. Understanding these factors will hopefully provide a more comprehensive picture of what influenza immunogenicity and protection means, which will be important in our effort to improve influenza vaccines.
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