Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles
2022
Bañó Polo, Manuel | Martínez Gil, Luis | Sánchez Del Pino, Manuel | Massoli, Alberto | Mingarro Muñoz, Ismael | León, Rubén | García Murria, María Jesús
BACKGROUND: SARS-CoV-2 is continuously disseminating worldwide. The development of strategies to break transmission is mandatory. AIM OF THE STUDY: To investigate the potential of cetylpyridinium chloride (CPC) as a viral inhibitor. METHODS: SARS-CoV-2 Virus Like-Particles (VLPs) were incubated with CPC, a potent surfactant routinely included in mouthwash preparations. RESULTS: Concentrations of 0.05% CPC (w/v) commonly used in mouthwash preparations are sufficient to promote the rupture of SARS-CoV-2 VLP membranes. CONCLUSION: Including CPC in mouthwashes could be a prophylactic strategy to keep SARS-CoV-2 from spreading.
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