A critical review to identify data gaps and improve risk assessment of bisphenol A alternatives for human health
2024
Mhaouty-Kodja, Sakina | Zalko, Daniel | Tait, Sabrina | Testai, Emanuela | Viguié, Catherine | Corsini, Emanuela | Grova, Nathalie | Buratti, Franca Maria | Cabaton, Nicolas | Coppola, Lucia | de la Vieja, Antonio | Dusinska, Maria | El Yamani, Naouale | Galbiati, Valentina | Iglesias-Hernández, Patricia | Kohl, Yvonne | Maddalon, Ambra | Marcon, Francesca | Naulé, Lydie | Rundén-Pran, Elise | Salani, Francesca | Santori, Nicoletta | Torres-Ruiz, Mónica | Turner, Jonathan | Adamovsky, Ondrej | Aiello-Holden, Kiara | Dirven, Hubert | Louro, Henriqueta | Silva, Maria João | Neuroplasticité des comportements de reproduction = Neuroplasticity of Reproductive Behaviors (NPS) ; Neuroscience Paris Seine (NPS) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) | ToxAlim (ToxAlim) ; Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Istituto Superiore di Sanità = National Institute of Health (ISS) | Università degli Studi di Milano = University of Milan (UNIMI) | Luxembourg Institute of Health (LIH) | Instituto de Salud Carlos III [Madrid] (ISCIII) | Norwegian Institute for Air Research (NILU) | Fraunhofer Institute for Biomedical Engineering [Sulzbach] (Fraunhofer IBMT) ; Fraunhofer (Fraunhofer-Gesellschaft) | Research Centre for Toxic Compounds in the Environment [Brno] (RECETOX / MUNI) ; Faculty of Science [Brno] (SCI / MUNI) ; Masaryk University [Brno] = Masarykova univerzita [Brno] = Université Masaryk [Brno] (MU / MUNI)-Masaryk University [Brno] = Masarykova univerzita [Brno] = Université Masaryk [Brno] (MU / MUNI) | German Federal Institute for Risk Assessment [Berlin] (BfR) | Norwegian Institute of Public Health [Oslo] (NIPH) | NOVA Medical School - Faculdade de Ciências Médicas (NMS) ; Universidade Nova de Lisboa = NOVA University Lisbon (NOVA) | Instituto Nacional de Saùde Dr Ricardo Jorge [Portugal] (INSA) | European Project: 101057014,Horizon Europe,PARC(2022) | European Project: 857560,H2020-WIDESPREAD-2018-01,CETOCOEN Excellence(2020)
International audience
Afficher plus [+] Moins [-]anglais. Bisphenol A (BPA), a synthetic chemical widely used in the production of polycarbonate plastic and epoxy resins, has been associated with a variety of adverse effects in humans including metabolic, immunological, reproductive, and neurodevelopmental effects, raising concern about its health impact. In the EU, it has been classified as toxic to reproduction and as an endocrine disruptor and was thus included in the candidate list of substances of very high concern (SVHC). On this basis, its use has been banned or restricted in some products. As a consequence, industries turned to bisphenol alternatives, such as bisphenol S (BPS) and bisphenol F (BPF), which are now found in various consumer products, as well as in human matrices at a global scale. However, due to their toxicity, these two bisphenols are in the process of being regulated. Other BPA alternatives, whose potential toxicity remains largely unknown due to a knowledge gap, have also started to be used in manufacturing processes. The gradual restriction of the use of BPA underscores the importance of understanding the potential risks associated with its alternatives to avoid regrettable substitutions. This review aims to summarize the current knowledge on the potential hazards related to BPA alternatives prioritized by European Regulatory Agencies based on their regulatory relevance and selected to be studied under the European Partnership for the Assessment of Risks from Chemicals (PARC): BPE, BPAP, BPP, BPZ, BPS-MAE, and TCBPA. The focus is on data related to toxicokinetic, endocrine disruption, immunotoxicity, developmental neurotoxicity, and genotoxicity/carcinogenicity, which were considered the most relevant endpoints to assess the hazard related to those substances. The goal here is to identify the data gaps in BPA alternatives toxicology and hence formulate the future directions that will be taken in the frame of the PARC project, which seeks also to enhance chemical risk assessment methodologies using new approach methodologies (NAMs).
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