Nutrimetabolomics: An Integrative Action for Metabolomic Analyses in Human Nutritional Studies
2019
Ulaszewska, M. M. | Weinert, C. H. | Trimigno, A. | Portmann, R. | Andres Lacueva, C. | Badertscher, R. | Brennan, L. | Brunius, C. | Bub, A. | Capozzi, F. | Cialie Rosso, M. | Cordero, C. E. | Daniel, H. | Durand, Stéphanie | Egert, B. | Ferrario, P. G. | Feskens, E. J. M. | Franceschi, P. | Garcia-Aloy, M. | Giacomoni, Franck | Giesbertz, P. | Gonzalez-Dominguez, R. | Hanhineva, K. | Hemeryck, L. Y. | Kopka, J. | Kulling, S. E. | Llorach, R. | Manach, Claudine | Mattivi, F. | Migné, Carole | Munger, L. H. | Ott, B. | Picone, G. | Pimentel, G. | Pujos-Guillot, Estelle | Riccadonna, S. | Rist, M. J. | Rombouts, C. | Rubert, J. | Skurk, T. | Sri Harsha, P. S. C. | van Meulebroek, L. | Vanhaecke, L. | Vazquez-Fresno, R. | Wishart, D. | Vergeres, G. | Department of Food Quality and Nutrition ; Research and Innovation Centre | Department of Safety and Quality of Fruit and Vegetables ; Federal Research Institute for Nutrition and Food | Department of Agricultural and Food Science ; Alma Mater Studiorum Università di Bologna = University of Bologna (UNIBO) | Method Development and Analytics Research Division ; Agroscope | Department of Nutrition and Food Sciences ; Utah State University (USU) | Universitat de Barcelona (UB) | Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CIBERFES) | Instituto de Salud Carlos III [Madrid] (ISCIII) | Institute of Food and Health | University College Dublin [Dublin] (UCD) | Department of Biology and Biological Engineering ; Chalmers University of Technology [Göteborg] | Department of Physiology and Biochemistry of Nutrition ; Max Rubner-Institut | Dipartimento di Scienza e Tecnologia ; Università degli studi di Torino = University of Turin (UNITO) | Nutritional Physiology ; Technische Universität Munchen - Technical University Munich - Université Technique de Munich (TUM) | Unité de Nutrition Humaine (UNH) ; Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]) | Plateforme Exploration du Métabolisme (PFEM) ; Institut National de la Recherche Agronomique (INRA)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-MetaboHUB-Clermont ; MetaboHUB-MetaboHUB | Division of Human Nutrition ; Wageningen University and Research [Wageningen] (WUR) | Computational Biology Unit [Bergen] (CBU) ; University of Bergen (UiB) | Molecular Nutrition Unit ; Technische Universität Munchen - Technical University Munich - Université Technique de Munich (TUM) | Department of Clinical Nutrition ; Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital | University of Eastern Finland | Department of Veterinary Public Health and Food Safety ; Istituto Superiore di Sanità = National Institute of Health (ISS) | Universiteit Gent = Ghent University = Université de Gand (UGENT) | Department of Molecular Physiology, Applied Metabolome Analysis ; Max Planck Institute of Molecular Plant Physiology (MPI-MP) ; Max-Planck-Gesellschaft-Max-Planck-Gesellschaft | Centro Agricoltura Alimenti Ambiente [San Michele All'adige] = Center Agriculture Food Environment [San Michele All'adige] (C3A) ; Università degli Studi di Trento = University of Trento (UNITN) | Università degli Studi di Trento = University of Trento (UNITN) | Food Microbial Systems Research Division ; Agroscope | Else Kröner Fresenius Center for Nutritional Medicine | Technische Universität Munchen - Technical University Munich - Université Technique de Munich (TUM) | ZIEL Institute for Food and Health | Departments of Biological Sciences and Computing Science ; University of Alberta | BioNH call under the Joint Programming Initiative "A Healthy Diet for a Healthy Life" (JPI-HDHL) Ministry of Education, Universities and Research (MIUR)2075Ministry of Economy and Competitiveness (MINECO) PCIN-2014-133Agencia de Gestio D'Ajuts Universitaris de Recerca Agaur (AGAUR) 2017SGR1566CIBERFES [European Regional Development Fund (FEDER) program from the European Union (EU)] Swiss National Science Foundation (SNSF) 40HD40 160618"Juan de la Cierva" program from MINECO FJCI-2015-26590 | ANR-11-INBS-0010,METABOHUB,Développement d'une infrastructure française distribuée pour la métabolomique dédiée à l'innovation(2011)
The life sciences are currently being transformed by an unprecedented wave of developments in molecular analysis, which include important advances in instrumental analysis as well as biocomputing. In light of the central role played by metabolism in nutrition, metabolomics is rapidly being established as a key analytical tool in human nutritional studies. Consequently, an increasing number of nutritionists integrate metabolomics into their study designs. Within this dynamic landscape, the potential of nutritional metabolomics (nutrimetabolomics) to be translated into a science, which can impact on health policies, still needs to be realized. A key element to reach this goal is the ability of the research community to join, to collectively make the best use of the potential offered by nutritional metabolomics. This article, therefore, provides a methodological description of nutritional metabolomics that reflects on the state-of-the-art techniques used in the laboratories of the Food Biomarker Alliance (funded by the European Joint Programming Initiative "A Healthy Diet for a Healthy Life" (JPI HDHL)) as well as points of reflections to harmonize this field. It is not intended to be exhaustive but rather to present a pragmatic guidance on metabolomic methodologies, providing readers with useful "tips and tricks" along the analytical workflow.
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