Tick-borne diseases in cattle: Applications of proteomics to develop new generation vaccines
2012
Marcelino, Isabel | de Almeida, André Martinho | Ventosa, Miguel | Pruneau, Ludovic | Meyer, Damien | Martinez, Dominique | Lefrancois, Thierry | Vachiery, Nathalie | Coelho, Ana Varela | Universidade Nova de Lisboa = NOVA University Lisbon (NOVA) | Instituto de Biologia Experimental e Tecnológica (IBET) | Institut de Systématique, Evolution, Biodiversité (ISYEB) ; Muséum national d'Histoire naturelle (MNHN)-École Pratique des Hautes Études (EPHE) ; Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA) | Contrôle des maladies animales exotiques et émergentes (UMR CMAEE) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA) | Département Systèmes Biologiques (Cirad-BIOS) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad) | Neuromimetic intelligence (CORTEX) ; INRIA Lorraine ; Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA) ; Institut National de Recherche en Informatique et en Automatique (Inria)-Université Henri Poincaré - Nancy 1 (UHP)-Université Nancy 2-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS)-Université Henri Poincaré - Nancy 1 (UHP)-Université Nancy 2-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS) | Instituto de Tecnologia Química e Biológica António Xavier (ITQB) ; Universidade Nova de Lisboa = NOVA University Lisbon (NOVA) | The authors acknowledge the financial support received from the Fundação para a Ciência e Tecnologia PTDC/CVT/114118/2009 research project and PEst-OE/EQB/LA0004/2011 research grant. Author André M. Almeida acknowledges financial support from the Ciência 2007 program, Isabel Marcelino from Post-doc grant SFRH/BPD/45978/2008 all from FCT/MCTES (Lisbon, Portugal). | Artwork collaboration by Simão Mateus is greatly appreciated. The authors are also thankful to Dr. Jennifer Pradel for her fruitful comments and suggestions in improving the manuscript.
International audience
Afficher plus [+] Moins [-]anglais. Tick-borne diseases (TBDs) affect 80% of the world's cattle population, hampering livestock production throughout the world. Livestock industry is important to rural populations not only as food supply, but also as a source of income. Tick control is usually achieved by using acaricides which are expensive, deleterious to the environment and can induce chemical resistance of vectors; the development of more effective and sustainable control methods is therefore required. Theileriosis, babesiosis, anaplasmosis and heartwater are the most important TBDs in cattle. Immunization strategies are currently available but with variable efficacy. To develop a new generation of vaccines which are more efficient, cheaper and safer, it is first necessary to better understand the mechanisms by which these parasites are transmitted, multiply and cause disease; this becomes especially difficult due to their complex life cycles, in vitro culture conditions and the lack of genetic tools to manipulate them. Proteomics and other complementary post-genomic tools such as transcriptomics and metabolomics in a systems biology context are becoming key tools to increase knowledge on the biology of infectious diseases. Herein, we present an overview of the so called "Omics" studies currently available on these tick-borne pathogens, giving emphasis to proteomics and how it may help to discover new vaccine candidates to control TBDs.
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