FT-IR coupled secondary metabolites profiling and biological activities of <i>Neolamarckia cadamba</i> leaves
2022
Jennifer George | Pratik Dhavan | Bhaskar Jadhav | Gangadhar Meshram | Vishwanath Patil
<i>Neolamarckia cadamba</i> is a pharmacologically significant tropical tree, exploited for various biological studies due to its rich secondary metabolites. In the present investigation, comparison of pharmacological and biological studies of five different extracts of <i>Neolamarckia cadamba</i> leaves have been carried out. This is the first report of phytochemical studies of five different extracts, coupled with FT-IR spectroscopy. Methanol extract (NCLE-D) was found to be rich in secondary metabolites. This extract also showed higher phenolic (279.023 GAE/g extract) and flavonoid (1067.48 QE/g extract) contents. Ethyl acetate extract (NCLE-C) and NCLE-D showed significant free radical scavenging activity with IC<sub>50</sub> 15.17 µg/mL and 16.12 µg/mL respectively compared to ascorbic acid (positive control) with IC<sub>50</sub> 5.22 µg/mL. NCLE-C exhibited antibacterial activity as well. These results suggest that <i>Neolamarckia cadamba</i> is capable of producing bioactive compounds especially from its leaves; hence, could be a valuable source of new drugs for treating diseases.
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